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Chronic psychological stress (PS) increases the infiltration of bone marrow-derived microglia into the PVN.

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posted on 26.11.2013, 03:18 by Koji Ataka, Akihiro Asakawa, Kanna Nagaishi, Kaori Kaimoto, Atsushi Sawada, Yuko Hayakawa, Ryota Tatezawa, Akio Inui, Mineko Fujimiya

(A, B) After chronic PS-loading for five days, the numbers of GFP-positive cells (green) in the PVN were significantly increased compared with sham-treated mice. Data are expressed as mean ± sem (PS: n = 6−7, sham: n = 5−11). #P < 0.05 with ANOVA followed by Tukey’s multiple comparison. *P < 0.05 with two-tailed Student’s t-test. (C) GFP-positive cells (green) overlapped with Iba-1 (red) in PVN from chronic PS-loaded mice but did not overlap with GFAP (red) in PVN from chronic PS-loaded mice. (D) Photograph of mice received irradiation with head protection and non-irradiated mice. (E, F) After chronic PS-loading for five days, the number of GFP-positive cells (green) in the PVN of mice received the irradiation with head protection was significantly increased compared with sham-treated mice. Data are expressed as mean ± sem. **P < 0.001 for PS (n = 8) to sham (n = 4) with two-tailed Student’s t-test. (G) GFP-positive cells (green) overlapped with Iba-1 (red) in PVN from chronic PS-loaded mice received the irradiation with head protection. PVN shown by dotted line. Scale bars: 50 µm.

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