Chromosome distribution and gene parameters of the murine LCGs.
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The percentage of LCGs (A, red solid circles) or LNCGs (B, blue solid circles), and gene density (open green circle) against the GC content of each autosome are plotted together. The gene density is defined as the mean gene numbers per megabase (Mb) in a chromosome. The average numbers of neighboring genes (C) for LCGs (red), non-liver circadian genes (NLCGs, orange), LNCGs (blue) or all genes in the genome (AG, green) are calculated in a given genomic length window (from zero to 1.5 Mb with a step length of 15 kb). The inset shows the portion from zero to 150 kb. Other genomic parameters include genomic length (D), 3′-UTR length (E), and CDS length (F) for LCGs, liver-expressed NLCGs (LNLCGs), LNCGs, and all liver-expressed genes (AL). The boxes depict data between the 25th and 75th percentiles with central horizontal lines and solid circles representing the median and mean values, respectively, and with whiskers showing the 5th and 95th percentiles. P-values are calculated based on the Wilcoxon rank sum test. (**), P-value<0.01. (***), P-value<0.001. NS, not significant.