Charge distribution of APC-MCR.

Charges present in the primary structure, putative phosphorylation sites and regulatory important motifs are indicated. A large number of putative phosphorylation sites scatter over the entire MCR (Phosida predictor for S/T phosphorylation). Two of the three 20 amino acid repeats (blue), bind to β-catenin (β). A short peptide stretch called “CID” (yellow) was recently implicated in Wnt/β-catenin downregulation [4,70].