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Characterizations of action potentials in NRVF infected with Ad-Kir2.1, Ad-NaV1.5 and Ad-Cx43.

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posted on 05.02.2013, 01:29 by Luqia Hou, Bin Hu, José Jalife

A. Action potentials were recorded from triple infected (K/Na/Cx43, 5/20/10 MOI) NRVF (left) but not in K/Cx43 (5/10 MOI) infected NRVF (right). B. Resting membrane potentials in uninfected, K/Na/Cx43 (5/20/10 MOI) infected and K/Cx43 (5/10 MOI) infected NRVF. C. APD80, APD50 and APD30 measured at different pacing cycle length. D. Representative action potential traces shows that resting membrane potentials and APDs are sensitive to BaCl2 (1 mM) but not 4-AP (1 mM). E. Resting membrane potentials measured before and after BaCl2 (1 mM) perfusion, and after washout in K/Na/Cx43 NRVF. F. Quantification of APD30, APD50 and APD80 before and after 4-AP perfusion. G. Quantification of APD30, APD50 and APD80 before and after BaCl2 perfusion. *: p<0.05.

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