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Download fileCharacterization of TFAM and Twinkle (TW) mice.
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posted on 2015-03-30, 03:15 authored by Masataka Ikeda, Tomomi Ide, Takeo Fujino, Shinobu Arai, Keita Saku, Takamori Kakino, Henna Tyynismaa, Toshihide Yamasaki, Ken-ichi Yamada, Dongchon Kang, Anu Suomalainen, Kenji Sunagawa(A) Expression of human TFAM (hTFAM) in left ventricle (LV) and aorta in TFAM and wild-type (WT) control mice. (B) mtDNA copy number in myocardium from TFAM and TW mice by real-time PCR (n = 4). (C) Expression of endogenous murine TFAM (mTFAM) and mitochondrial complex proteins in LV of TFAM and TW mice. (D) Transcription of mtDNA-encoded genes in TFAM and TW mice (n = 6). Data are expressed as mean ± SEM. *P < 0.05 vs. WT, **P < 0.01 vs. WT, analyzed by Student’s t-test.
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WT mice.ConclusionsThe overexpressionFacilitates Cardioprotection AssociatedLimited Mitochondrial Oxidative Stress BackgroundMitochondrial DNATG mice displayTg micemitochondrial protein oxidationhfH 9c rat cardiomyoblastsvoReactive oxygen speciescopy number decreasesmtDNA copy numbermitochondrial reactive oxygen speciesmmpmitochondrial oxidative stressmitoROStfamoverexpressing Twinkle helicaseTwinkle Increases mtDNA Copy Number
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