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Characterization of TFAM and Twinkle (TW) mice.

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posted on 2015-03-30, 03:15 authored by Masataka Ikeda, Tomomi Ide, Takeo Fujino, Shinobu Arai, Keita Saku, Takamori Kakino, Henna Tyynismaa, Toshihide Yamasaki, Ken-ichi Yamada, Dongchon Kang, Anu Suomalainen, Kenji Sunagawa

(A) Expression of human TFAM (hTFAM) in left ventricle (LV) and aorta in TFAM and wild-type (WT) control mice. (B) mtDNA copy number in myocardium from TFAM and TW mice by real-time PCR (n = 4). (C) Expression of endogenous murine TFAM (mTFAM) and mitochondrial complex proteins in LV of TFAM and TW mice. (D) Transcription of mtDNA-encoded genes in TFAM and TW mice (n = 6). Data are expressed as mean ± SEM. *P < 0.05 vs. WT, **P < 0.01 vs. WT, analyzed by Student’s t-test.