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Changes in LSD1 activity affect cell proliferation in the A549 and H460 cell lines, as detected by immunofluorescence.

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posted on 20.02.2013, 06:47 by Tangfeng Lv, Dongmei Yuan, Xiaohui Miao, Yanling Lv, Ping Zhan, Xiaokun Shen, Yong Song

Images are shown at ×20 magnification. Green, red and blue fluorescence represent LSD1, BrdU and Topro-3, respectively. The proliferation significantly increased in the A549 cells after transfection of the Flag-LSD1 plasmid. However, proliferation decreased in the H460 cells after transfection of the LSD1 siRNA plasmid. Pargyline treatment reduced proliferation in both cell lines. Topro-3 staining shows nuclear localization, and BrdU staining shows the proliferating cells.

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