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COX gene expression in tissue from atherosclerotic apoE−/− mice.

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posted on 02.06.2014, 04:41 authored by Nicholas S. Kirkby, Martina H. Lundberg, William R. Wright, Timothy D. Warner, Mark J. Paul-Clark, Jane A. Mitchell

COX-2 (ptgs2) (a) and COX-1 (ptgs1) (b) gene expression levels measured by quantitative RT-PCR in a panel of tissues from atherosclerotic apoE−/− mice indicated that COX-1 was expressed at a similar level and was the dominant isoform across all studied tissues. COX-2 expression showed more variation across tissues, with the highest levels present in the thymus, which also had the greatest COX-2:COX-1 expression ratio of any tissue examined (c). n = 4-6.