CG14122 is homologous to human Smyd4.

A, Domain structure of human Smyd4 (hSmyd4) and Drosophila CG14122 (dSmyd4). T, tetratricopeptide repeat motif; S-, first part of the SET domain; MYND, MYND zinc fingers; -ET, second part of the SET domain, including cysteine-rich post-SET region. B, Alignment of the SET domains of dSmyd4 and human Smyd4, Smyd1, Smyd2, SUV39h1 and SET7. C, Alignment of the MYND domains of dSmyd4 and human Smyd4, Smyd1, Smyd2, MTG8 and BS69. In B and C identical residues are shaded black and similar residues are shaded grey.