CCL5-induced tumor-promoting properties in CRC cells.

(A, C, E, G) Proliferation of the CT26 and HT29 cells was assessed in response to a 5-day treatment with base medium alone (BSA, open bars), with serum-enriched medium (FBS, hatched bars) or with the indicated concentrations of recombinant CCL5 (filled bars), in the presence or in the absence of TAK-779 or anti-CCL5 antibodies (at the indicated concentrations). (B, D, F, H) CRC cells were assayed for chemotaxis in response to base medium alone (BSA, open bars), to serum-enriched medium (FBS, hatched bars) or to the indicated concentrations of recombinant CCL5 (filled bars), in the presence or in the absence of TAK-779 or anti-CCL5 antibodies. Results represent the mean±s.e.m. of six determinations. * p<0.05, ** p<0.01, *** p<0.001.