CCL3L1-CCR5 GRGs influence median time-from-seroconversion to CD4 cell count thresholds that might be used to guide initiation of HAART, and time from a high to a low CD4 cell count.
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In Panel A, KM plots show the time-from-seroconversion to arrival at <450 (left), <350 (center) or <200 (right) CD-cells/mm3. In Panel B, the KM plots are for progression from <450 to <200 CD4-cells/mm3 in all seroconverters (left) or seroconverters recruited and followed during the years 1990 to 1999, a time-period in which antiretroviral therapy was available (right). The color codes for the KM plots in panel B are: blue, low GRG; brown, moderate and high GRGs combined into a single category; and black, all subjects. Overall P values are at the top of each plot. Color-coded numbers at the upper right of the KM plots represent the median time-to-event, that is, from seroconversion to the indicated CD4 cell count. In panel A, P values for differences in median time-to-event relative to those with a low GRG were: *, 0.1131; †, 0.0089; ‡, 0.0030; §, 0.0005; ¶, 0.0001; and ∥, 9.6×10−7. RH, relative hazard; CI, confidence interval. P values in Panel B are adjusted for the steady-state viral load, baseline CD4 and best DTH response recorded during disease course, and subjects with a moderate or high GRG were combined into a single category.