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CCL3L1-CCR5 GRGs influence median time-from-seroconversion to CD4 cell count thresholds that might be used to guide initiation of HAART, and time from a high to a low CD4 cell count.

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posted on 08.09.2008 by Hemant Kulkarni, Brian K. Agan, Vincent C. Marconi, Robert J. O'Connell, Jose F. Camargo, Weijing He, Judith Delmar, Kenneth R. Phelps, George Crawford, Robert A. Clark, Matthew J. Dolan, Sunil K. Ahuja

In Panel A, KM plots show the time-from-seroconversion to arrival at <450 (left), <350 (center) or <200 (right) CD-cells/mm3. In Panel B, the KM plots are for progression from <450 to <200 CD4-cells/mm3 in all seroconverters (left) or seroconverters recruited and followed during the years 1990 to 1999, a time-period in which antiretroviral therapy was available (right). The color codes for the KM plots in panel B are: blue, low GRG; brown, moderate and high GRGs combined into a single category; and black, all subjects. Overall P values are at the top of each plot. Color-coded numbers at the upper right of the KM plots represent the median time-to-event, that is, from seroconversion to the indicated CD4 cell count. In panel A, P values for differences in median time-to-event relative to those with a low GRG were: *, 0.1131; †, 0.0089; ‡, 0.0030; §, 0.0005; ¶, 0.0001; and ∥, 9.6×10−7. RH, relative hazard; CI, confidence interval. P values in Panel B are adjusted for the steady-state viral load, baseline CD4 and best DTH response recorded during disease course, and subjects with a moderate or high GRG were combined into a single category.

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