Brain-derived cell lines express markers for mesenchymal stem cells and pericytes but not for glial or neuronal precursors.
figure
posted on 2013-02-20, 06:26 authored by Gesine Paul, Ilknur Özen, Nicolaj S. Christophersen, Thomas Reinbothe, Johan Bengzon, Edward Visse, Katarina Jansson, Karin Dannaeus, Catarina Henriques-Oliveira, Laurent Roybon, Sergey V. Anisimov, Erik Renström, Mikael Svensson, Anders Haegerstrand, Patrik Brundin(A) Representative histogram of flow cytometry analysis of cortical line and (B) ventricular zone line. Progenitors from all donors and both regions highly express MSC (CD90, CD73, CD105, CD29, CD166 and CD49d) and pericyte markers (CD140b/PDGFR-β, RGS5, CD146, Nestin, α-SMA and NG2). They do not express hematopoietic (CD45), endothelial (CD31, CD34), microglial (CD14, CD11), glial or neuronal precursor cell markers (GFAP, O4) or myofibroblast markers (CD56), (green = isotype, red = respective marker).
