Brain areas significantly correlated with the pleasurability of scratching (pink) and with itch relief (blue) induced by actively scratching an itch, as identified by multiple regression analysis.
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VAS ratings of pleasurability and itch relief (calculated as the difference in itch ratings before and after scratching) were used as covariates of interest. PAG = periaqueductal gray; VTA = ventral tegmental area; SN= substantia nigra; ACC = anterior cingulate cortex; PCC = posterior cingulate cortex; rmTgm = rostromedial tegmentum. Talairach standard space coordinates (x, y, z). Areas significantly correlated with a Z score > 2.3, p < 0.05 are displayed. The color tones displayed correspond to Z score values as depicted in the color bars (at the same scale). R = Right; L = Left.