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Both Leg1a and Leg1b are essential for normal liver development.

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posted on 09.08.2011 by Changqing Chang, Minjie Hu, Zhihui Zhu, Li Jan Lo, Jun Chen, Jinrong Peng

(A) leg1-MOATG (ATG-MO), leg1a-MO (1a-MO) and leg1b-MO (1b-MO) all resulted in small liver phenotype but with different severity. (B) Statistical analysis of liver size in leg1-MOATG (ATG-MO), leg1a-MO (1a-MO) or leg1b-MO (1b-MO) morphants based on WISH signal intensity of fabp10a. Signal intensity (Y-axis) was plotted against body length (X-axis). 20–23 embryos were used for statistical analysis in each case. (C) WISH using fabp10a probe to examine rescue of the small liver phenotype caused by leg1-MOATG with leg1a (1a mRNA), leg1b (1b mRNA) mRNA, or combination of leg1a and leg1b mRNA (1a+1b mRNA). (D) Statistical analysis of liver size in each individual leg1-MOATG morphant based on WISH signal intensity of fabp10a. 19–23 embryos were used for statistical analysis in each case except for WT (14 embryos were used).

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