Body composition, blood glucose, and serum factors in C57BL/6 mice following 21 weeks of diet treatment.
Calorie restriction (CR) decreased A, body weight (reported up to 20 weeks on diets, before tumor cell injection); B, percent body fat (at 21 weeks on diet); and C, fasting blood glucose (at 21 weeks on diet) relative to CON diet (n = 15/group). Data shown represent mean ± SD. CR altered mean fasting serum levels of D, insulin; E, IGF-1; F, leptin; and G, adiponectin (n = 8/group). Data shown represent mean ± SEM. * denotes significant differences between CR and CON. CR, calorie restriction; CON, control diet; IGF-1, insulin-like growth factor-1.