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Biophysical properties of WT and mutants TRPM4 channel in whole-cell configuration.

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posted on 30.01.2013, 02:31 by Hui Liu, Stéphanie Chatel, Christophe Simard, Ninda Syam, Laurent Salle, Vincent Probst, Julie Morel, Gilles Millat, Michel Lopez, Hugues Abriel, Jean-Jacques Schott, Romain Guinamard, Patrice Bouvagnet

(A): Representative current tracings recorded in the whole cell conditions (ramp protocol under the traces) (B): Mean current density for WT and mutants estimated using the maximal current recorded during the ending step of 20 ms at Vm = +100 mV (see A) and reported to cell capacitance. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, n.s.: not significant. Numbers in bars = number of experiments. Error bar: standard error of the mean.