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Beneficial long term results of ATG treatment six weeks after AMI.

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posted on 2012-12-20, 00:24 authored by Michael Lichtenauer, Michael Mildner, Gregor Werba, Lucian Beer, Konrad Hoetzenecker, Andrea Baumgartner, Matthias Hasun, Stefanie Nickl, Andreas Mitterbauer, Matthias Zimmermann, Mariann Gyöngyösi, Bruno Karl Podesser, Walter Klepetko, Hendrik Jan Ankersmit

(a) Hearts obtained from untreated control animals evidenced an extensive scar size and signs of ventricular dilation, whereas scar size was reduced in ATG injected rats with a better preserved ventricular geometry (b). ATG injection after AMI resulted in a reduction of scar size from 24.95% of the left ventricle in untreated controls to 11.43% in the treatment group, p<0.01, n = 9–13 per group). Parameters of cardiac function (ejection fraction, shortening fraction, left ventricular end-diastolic diameter and left ventricular end-systolic diameter) were significantly improved by ATG (d,e,f,g).


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