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Bacterial colonization, colonic mucosa inflammation and translocation in CEABAC10 mice infected with LF82ΔfimH/fimHLF82 or LF82ΔfimH/fimHK12 mutants.

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posted on 2013-01-24, 00:51 authored by Nicolas Dreux, Jérémy Denizot, Margarita Martinez-Medina, Alexander Mellmann, Maria Billig, Dagmara Kisiela, Sujay Chattopadhyay, Evgeni Sokurenko, Christel Neut, Corinne Gower-Rousseau, Jean-Frédéric Colombel, Richard Bonnet, Arlette Darfeuille-Michaud, Nicolas Barnich

(A) Quantification of LF82-ΔfimH/fimHLF82 (black square) or LF82-ΔfimH/fimHK12 (white square) bacteria in the feces of CEABAC10 mice receiving 0.25% DSS in drinking water after oral infection with 109 bacteria on day 0. (B) Quantification of colonic mucosal-associated LF82-ΔfimH/fimHLF82 or LF82-ΔfimH/fimHK12 bacteria on day of sacrifice. (C) Quantification of bacteria on day of sacrifice in the liver and spleen. (D) DAI was performed for CEABAC10 transgenic mice infected with (black square) LF82ΔfimH/fimHLF82 or with (white square) LF82ΔfimH/fimHK12. (E) Il-1β secretion by colonic mucosa. (F) Histopathological scoring for several parameters of colonic inflammation was performed for CEABAC10 transgenic mice infected with (black square) LF82ΔfimH/fimHLF82 or with (white square) LF82ΔfimH/fimHK12. * P<0.05; ** P<0.01; and *** P<0.001.

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