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Association analysis of WTCCC type 1 diabetes data.

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posted on 06.06.2013, 01:05 by Xiaoming Jia, Buhm Han, Suna Onengut-Gumuscu, Wei-Min Chen, Patrick J. Concannon, Stephen S. Rich, Soumya Raychaudhuri, Paul I.W. de Bakker

We imputed classical HLA alleles and polymorphic amino acids in 1,963 cases and 2,939 controls using the T1DGC reference panel, and tested all variants for association with logistic regression. Of all variants tested, the top hit maps to amino acid position 57 in HLA-DQβ1, consistent with a previous study [16].