Application of the coarse-grained model to predict the chemical denaturant induced unfolding.

(A) The computed free energy in water and m-value for the coarse grain model with the elementary parameters from Figure 6, and T = 0.9147 T_f, α = 1.7 (closed circles), and the experimentally determined values (open circles). (B) Folding curves predicted for TPR proteins of different lengths (from 5 to 30), at T = 0.9 T_f. (C) Folding curves predicted for TPR proteins of different lengths (from 5 to 30), at T = 1.1 T_f.