Antiproliferative and apoptotic effects of sorafenib.
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Following incubation with increasing doses of sorafenib, viable cell counts and apoptotic cell death were assessed by annexin-V/PI double staining and flow cytometry analysis. (A) Viable cell counts upon exposure to 0 (▪), 5 (□) and 10 (•) µM sorafenib. Viable cells are expressed as fold increase (FI) of annexin-V−/PI− cells after 24 and 48 hours of incubation with sorafenib as compared to day 0. (B) Cell death following 24 (□) or 48 (▪) hours sorafenib exposure. Percentages of cell death include annexin-V+/PI− plus annexin-V+/PI+ plus annexin-V−/PI+ cells. Values refer to four independent experiments. * p≤0.001, ° p≤0.01, and ≠ p≤0.05, compared to controls.