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Anti-tumor effect on TLT-tumor-bearing mice treated with PTX-loaded micelles in combination with irradiation.

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posted on 20.02.2013, 02:37 by Fabienne Danhier, Pierre Danhier, Nicolas Magotteaux, Géraldine De Preter, Bernard Ucakar, Oussama Karroum, Bénédicte Jordan, Bernard Gallez, Véronique Préat

(A) Anti-tumor effect. PTX is administered at a dose of 80 mg/kg. Six groups of mice were treated: Group 1: PBS injection (n = 6); Group 2: PTX-loaded micelles (n = 6); Group 3: Irradiation with 10 Gy of X-rays (n = 6); Group 4: PTX-loaded micelles 24 h before irradiation with 10 Gy of X-rays (n = 8); Group 5: PTX-loaded micelles 24 h before irradiation with 10 Gy of X-rays. The irradiated legs of mice were clamped (n = 7); Each point represents the mean of tumor size ± SEM. (B) Survival rates of tumor-bearing mice. (C) Individual evolution of the TLT growth as a function of time. ** p<0.001; ***p<0.0001.

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