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Anchor insertion.

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posted on 17.06.2011, 01:13 by Steven M. Lewis, Brian A. Kuhlman

Panel A demonstrates the AnchoredDesign process with a simple cartoon. At left, we start with a known interaction between a target (cyan) and a natural partner (orange) with a characteristic interaction (the anchor, yellow). In the middle, we graft the anchor into the scaffold (magenta) to create a rough starting structure. At right, we fill out the scaffold-target interface with the AnchoredDesign protocol. Panel B demonstrates the process using protein structures for greater clarity (using the same color scheme).


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