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An EvoPrint view of a genomic segment of human DNA selected and then screened for mutations.

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posted on 31.07.2012, 02:41 by Erich Roessler, Ping Hu, Sung-Kook Hong, Kshitij Srivastava, Blake Carrington, Raman Sood, Hanna Petrykowska, Laura Elnitski, Lucilene A. Ribeiro, Antonio Richieri-Costa, Benjamin Feldman, Ward F. Odenwald, Maximilian Muenke

(A) A multiple species comparison was performed where bases conserved in all but one of the test species, relaxed EvoPrint, appear as black uppercase letters (these alignments were among Human, Marmoset, Chimpanzee, Rhesus-Monkey, Horse, Platypus and Opossum) and are displayed in context with non-conserved bases (lower case, grey) spanning the entire 804 bp element shown in blue. (B) Analysis of the repetitive and palindromic structure of the EvoPrint using cis-Decoder identifies further substructure of its conserved sequence blocks (CSB). Distinct elements (>6 bp) are highlighted in yellow. These CSC analyzed and presented are contained within the element in common [>50% conservation between human and zebrafish, outlined in red] where most variants were detected.

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