Amplitude Distribution of Unitary EPSPs Arriving at Pyramidal Cells (Bottom) and Fast-Spiking Interneurons (Top) from Local Pyramidal Cells in Layers 2/3 of the Human Cortex

Note the unitary EPSPs of enormous amplitude selectively targeting fast-spiking interneurons. Inset, amplitude distribution of spontaneous EPSPs arriving at presynaptic human pyramidal cells (red) and postsynaptic interneurons (blue). The distribution of spontaneous EPSPs was shifted towards significantly higher amplitudes in interneurons relative to pyramidal cells.