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Amorphous silica induces endo-lysosomal leakage in MH-S cells.

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posted on 02.02.2011, 00:26 by Lindsey M. Costantini, Renée M. Gilberti, David A. Knecht

MH-S cells are pre-loaded with 20 kD FITC-dextran [1 mg/ml] for × hours. Fluorescence images of cells untreated cells (A) or treated with 3 µm spherical, amorphous silica particles [25 µg/cm2] for 1.5 hours (B). The punctate endosomal distribution of FITC-dextran is converted to a diffuse cytoplasmic localization after treatment of cells with amorphous silica.

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