Age-dependent upregulation of LPS-induced production of TNF-α, IP-10, IL-12p70 and IFN-γ.
Whole blood samples were stimulated with LPS and culture supernatants were collected after 16–18 h. Production in the different infant groups was compared to adult values. Cord blood (CB, n = 13), 3-month (3 m, n = 15), 6-month (6 m, n = 8), 9-month (9 m, n = 9), 12-month (12 m, n = 9) old infants and healthy adults (n = 10). Data are represented as median+interquartile range. *p<0.05, **p<0.01, ***p<0.001 as compared to stimulated adult samples.