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Age-dependent upregulation of LPS-induced production of TNF-α, IP-10, IL-12p70 and IFN-γ.

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posted on 21.02.2013 by Muriel Nguyen, Elke Leuridan, Tong Zhang, Dominique De Wit, Fabienne Willems, Pierre Van Damme, Michel Goldman, Stanislas Goriely

Whole blood samples were stimulated with LPS and culture supernatants were collected after 16–18 h. Production in the different infant groups was compared to adult values. Cord blood (CB, n = 13), 3-month (3 m, n = 15), 6-month (6 m, n = 8), 9-month (9 m, n = 9), 12-month (12 m, n = 9) old infants and healthy adults (n = 10). Data are represented as median+interquartile range. *p<0.05, **p<0.01, ***p<0.001 as compared to stimulated adult samples.

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