Age-dependent upregulation of LPS-induced production of TNF-α, IP-10, IL-12p70 and IFN-γ.
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posted on 2013-02-21, 01:39 authored by Muriel Nguyen, Elke Leuridan, Tong Zhang, Dominique De Wit, Fabienne Willems, Pierre Van Damme, Michel Goldman, Stanislas Goriely<p>Whole blood samples were stimulated with LPS and culture supernatants were collected after 16–18 h. Production in the different infant groups was compared to adult values. Cord blood (CB, n = 13), 3-month (3 m, n = 15), 6-month (6 m, n = 8), 9-month (9 m, n = 9), 12-month (12 m, n = 9) old infants and healthy adults (n = 10). Data are represented as median+interquartile range. *<i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001 as compared to stimulated adult samples.</p>
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