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Age-dependent decline of cobblestone area formation in Npm1wt/c+ mice.

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posted on 30.11.2012, 00:55 by Shiu-Huey Chou, Bor-Sheng Ko, Ji-Shain Chiou, Yueh-Chwen Hsu, Mong-Hsun Tsai, Yu-Chiao Chiu, I-Shing Yu, Shu-Wha Lin, Hsin-An Hou, Yi-Yi Kuo, Hsiu-Mei Lin, Ming-Fang Wu, Wen-Chien Chou, Hwei-Fang Tien

(A) The cobblestone area formation (arrows) is obviously inhibited in Npm1wt/c+ HSPC. (B) The cobblestone area numbers are also much lower in mutant mice. The difference seems more augmented as mice became older (n = 7 each). (C) The mutant mice with MPD exhibited even more severe compromised cobblestone area formation when compared with mutant but non-MPD mice (P<0.001, one bar represents triplicate experiments from one mouse).


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