Administration of TCDD after initiation of the immune response does not result in immunosuppression.
A) Clinical scores of mice immunized with MOG/CFA which received either vehicle (filled circles) or TCDD i.p. at the time of immunization (open circles) or 7 days after immunization (open squares). Table showing incidence, mean day of onset and mean maximum score of disease. Data shown as mean ± SEM are representative of 2 experiments, **** p<0.0001, two-way ANOVA followed by Dunnet post-test. B) Number of Foxp3+ and of IL-17A+ T cells recovered at day 9 after immunization from draining lymph nodes of immunized mice who received vehicle, TCDD on day 0 or TCDD on day 7 after immunization; n = 4. Data shown as mean ± SEM are representative of 2 experiments, *p<0.05, **p<0.01 in one-way ANOVA followed by Dunnet post-test.