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Adaptation of synapse-driven spikes and postsynaptic currents.

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posted on 08.12.2014 by Haitao Wang, Yi-Fan Han, Ying-Shing Chan, Jufang He

A, Synapse-driven spikes were elicited with a similar latency as EPSPs. B, Representative traces showing the adaptation of synapse-driven spikes in response to extracellular current stimulation. C, Sample traces of an EPSC (left) and IPSC (right) from two pairs of cortical neurons stimulated at 10 Hz and recorded using dual patch-clamp techniques. D, Normalized postsynaptic current amplitude plotted against stimulus number (n = 27 for EPSC and n = 14 for IPSC).