Ad-CXCR4 transfection protects EPCs from HG-induced dysfunction and apoptosis via activating Akt/eNOS pathways.
Figures are generally photos, graphs and static images that would be represented in traditional pdf publications.
Representative tube formation pictures (A1–A8) and summarized data (A9) in different treatment groups. A1: Ad-null-EPCs+Con; A2: Ad-null-EPCs+Osm; A3: Ad-null-EPCs+HG; A4: Ad-CXCR4-EPCs+Con; A5: Ad-CXCR4-EPCs+Osm; A6: Ad-CXCR4-EPCs+HG; A7: Ad-CXCR4-EPCs+HG+LY294002; A8: Ad-CXCR4-EPCs+HG+L-NAME. Scale bar: 600 µm. Summarized data on migration ability (B) and the percentage of EPC apoptosis (C) in different treatment groups. *P<0.05, **P<0.01 vs. Ad-null-EPCs or Ad-null-EPCs+Osm; ++P<0.01 vs. HG+Ad-null-EPCs; #P<0.05, ##P<0.01 vs. HG+Ad-CXCR4-EPCs; §P<0.05 vs. HG+Ad-CXCR4-EPCs+LY294002, n = 6/group. Con: control (basal medium); Osm: osmotic control; HG: high glucose medium; Ad-null-EPCs: EPCs transfected with Ad-null; Ad-CXCR4-EPCs: EPCs transfected with Ad-CXCR4.