Achieving high frequency requires simultaneous NMDA receptor stimulation of distal dendrites.
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(A) The dendrites receiving NMDA stimulation are marked in read ( = 14 mS/cm2). (B) Firing a somatic spike (black) requires simultaneous firing of the three dendrites. The membrane potential for the dendrites 1 and 2 are shown in red and blue respectively. A spike in dendrite 1 alone evokes only a small spikelet in the soma.