Fig_6.tif (1.35 MB)
Acetone extract of P. coriacea and physciosporin reduced RhoGTPase activity.
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posted on 2015-09-15, 03:17 authored by Yi Yang, So-Yeon Park, Thanh Thi Nguyen, Young Hyun Yu, Tru Van Nguyen, Eun Gene Sun, Jayalal Udeni, Min-Hye Jeong, Iris Pereira, Cheol Moon, Hyung-Ho Ha, Kyung Keun Kim, Jae-Seoun Hur, Hangun Kim(A-B) The levels of GTP-bound Cdc42 (A) and Rac1 (B) were measured in A549 cells treated with 5 μg/mL of acetone extract of P. coriacea or physciosporin. GTP-Cdc42 and -Rac1 were measured using GST-PBD. The total amounts of Cdc42 and Rac1 were shown to measure relative activity. Quantitative data were obtained from three independent experiments, n = 3. Data represent the mean ± S.E.M. (standard error of the mean). ***p<0.001 compared to DMSO-treated A549 cells.
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metastasis suppressor genemetabolitekaiD.Jnovel lichenacetone extractslung cancer cell motilityphysciosporinmRNA levelsPCR analysis13 lichen samplesKITENINlung cancer cellsinvasion assaysepidermal growth factor stimulationmetastasis enhancer geneInhibits Lung Cancer Cell Motility LichensCdc 42novel mechanismsHook fPseudocyphellaria coriaceaapRac 1 activitiesPhysciosporin treatment
