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A hypothetical model for NELL2 action in the neuronal differentiation of P19 cells.

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posted on 21.01.2014, 03:43 by Dong Hee Kim, Han Rae Kim, Eun Jung Choi, Dong Yeol Kim, Kwang Kon Kim, Byung Sam Kim, Jeong Woo Park, Byung Ju Lee

RA diffuses across the plasma membrane and RA-receptor (RAR/RXR) complexes bind to the RA response elements (RAREs) of the NELL2 promoter region. These complexes transcriptionally activate NELL2 expression, and, in turn, released NELL2 stimulates the ERK pathway via as yet unknown receptor signaling. The activated ERK increases synthesis of N-cadherin, which mediates cell-cell adhesion and neuronal differentiation.