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Download fileARID1A gene promoter methylation levels between RNA high (n = 11) and low (n = 22) expression groups.
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posted on 2013-01-21, 15:00 authored by Xianyu Zhang, Qian Sun, Ming Shan, Ming Niu, Tong Liu, Bingshu Xia, Xiaoshuan Liang, Wei Wei, Shanshan Sun, Youxue Zhang, Xiaolong Sean Liu, Qingbin Song, Yanmei Yang, Yuyan Ma, Yang Liu, Long Yang, Yanlv Ren, Guoqiang Zhang, Da PangRelative methylation levels were analyzed with MeDIP-qPCR. Promoter methylation levels (blue bar) were significantly higher in low expression group (green bar) compared with high expression group (green bar) (p<0.001).
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tumor suppressor genepromoter hypermethylationARID 1A Genepromoter methylation levelPCR product Sanger sequencingbreast tissue counterpartsexpression groupcopy number variation detectionhistone modification levelscopy number variationARID 1A gene copy numberARID 1A mRNART-PCRhistone modificationductal carcinomasexon novel mutationsARID 1A promoter hypermthylationgene copy number variationexon mutation rate3KMany Invasive Breast Cancers ARID 1ALow mRNA Expression
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