ALK fusion in colorectal cancer (Case one).
figureposted on 2015-12-18, 11:22 authored by Jianming Ying, Chen Lin, Jian Wu, Lei Guo, Tian Qiu, Yun Ling, Ling Shan, Haitao Zhou, Dongbing Zhao, Jian Wang, Jianwei Liang, Jianjun Zhao, Yuchen Jiao, Ning Lu, Hong Zhao
A-B, Immunohistochemistry showed cytoplasmic immunoreactivity for ALK protein expression (A, 20×; B, 200×). C, No immunoreactivity was found in normal tissue (200×). D, fluorescence in situ hybridization (FISH) performed with Vysis LSI ALK Dual color Break-Apart FISH probes detected ALK fusion as split red and green signals (arrows) (1000×).
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ALK Fusion Genestarget gene enrichmenttract cancer casesDigestive Tract Cancerihcnovel SPTBN 1emlALK fusionnovel fusion partner.ResultsAmongChinese CRC patientstmaAnaplastic Lymphoma Kinase Rearrangementgene sequencing.ConclusionsThe incidence ratetract cancer patients.Patientspolymerase chain reaction457 colorectal cancerChinese Population BackgroundAnaplastic lymphoma kinaseALK gene fusionALK gene rearrangement