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AKT pathway model.

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posted on 04.08.2014, 03:12 by Yohei Murakami

(A) Structure of the AKT pathway model. The input signal is insulin. The output signal is pAKT. Solid arrows represent mass flows. Solid arrows directional to a lined circle represent degradation processes. Solid arrows with black circles represent association/dissociation processes. Dotted arrows represent enhancement of the processes. (B) Experimental data (red points) and simulated trajectory (green trajectory) of pAKT in response to the step stimulation of 1 nM insulin. (C), (D), (E) Reproduction of the experimental data. Simulations were run with the posterior parameter ensemble in response to the step stimulation of 1 nM insulin. (C) Annealing schedule: (ε0, ε1, ε2, ε3, ε4, ε5, ε6, ε7, ε8, ε9, ε10, ε11, ε12, ε13, ε14) = (∞, 1.5, 1.0, 0.75, 0.5, 0.25, 0.1, 0.09, 0.08, 0.07, 0.06, 0.05, 0.04, 0.03, 0.02). (D) Annealing schedule: (ε0, ε1, ε2, ε3, ε4, ε5, ε6, ε7, ε8, ε9, ε10, ε11, ε12, ε13, ε14, ε15) = (∞, 1.5, 1.0, 0.75, 0.5, 0.25, 0.1, 0.09, 0.08, 0.07, 0.06, 0.05, 0.04, 0.03, 0.02, 0.01). (E) Annealing schedule: (ε0, ε1, ε2, ε3, ε4, ε5, ε6, ε7, ε8, ε9, ε10, ε11) = (∞, 1.5, 1.0, 0.75, 0.5, 0.25, 0.1, 0.09, 0.08, 0.07, 0.06, 0.05). Blue-colored area is the probability density consists of the simulated trajectories. Red points are the experimental data.

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