(A-C) The values of the difference in betweenness centrality (BC) with respect to the WT state plotted as a function of residue index for three systems(A), meR83; (B), meR152; (C), meR83,152.

The horizontal lines correspond to the value ±0.1. The data are colored according to domain/subdomain color as shown in Fig 1A. Data shows a large change in normalized BC value due to the methylation. Residues with the largest positive change in normalized BC value for (D) meR83, (F) meR152, and (H) meR83,152. Residues with the largest negative change in normalized BC value for (E) meR83, (G) meR152, and (I) meR83,152. The DNA polymerase β subdomains corresponding to those residues are also mentioned next to the residue number.