5-HTTLPR genotype effects on association between anterior insula activation and intolerance of uncertainty in patients.
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Patients with two LA alleles (n = 14) and higher scores on the Intolerance of Uncertainty Scale (IUS) had more anterior insula activation across aversive and neutral valences in anticipation of and response to affective pictures in the a priori defined anterior insula region of interest (inset). B) A voxelwise regression for patients with two LA alleles indicated a positive association between the IUS and bilateral anterior insula activation (inset) at p<0.05, corrected. No associations with the IUS were observed for patients with at least one S or LG allele (n = 36). The association remained significant even after removing the individual with the highest insula activation, r = 0.44, p = 0.001. Y-axes display mean percent signal change averaged over displayed ROIs/clusters. Solid regression lines indicate all patients, triangular markers and black dashed lines indicate patients with two LA alleles, and circular markers and gray dashed lines indicate patients who are S/LG carriers. Z-values on axial images indicate Tailarach and Tournoux coordinates for the AFNI MNI-152 brain used for normalizing.