5-HT3A-An = 1,3,5 receptors desensitize more rapidly that 5-HT3A-An = 2,4,6,7.
Representative traces for oocytes expressing 5-HT3A- (A) WT (B) A7, A6, A4, A2 (C) and A5, A3, A1 receptors during prolonged exposure to 10 µM 5-HT. (A) The desensitizing component of the current from an oocyte expressing WT 5-HT3A receptors is fit by a single exponential decay function. The dots represent the fitted line which overlays the current trace. (A). Note the difference in the time scale between panels (B) and (C). The A5, A3, and A1 receptors desensitized an order of magnitude faster than A7, A6, A4 and A2 receptors which were similar to WT.