1,25(OH)2D3 inhibits activation of TLR8 signaling cascade in EAE.
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posted on 2013-03-15, 13:46 authored by Bo Li, David J. Baylink, Chandra Deb, Claudia Zannetti, Fatima Rajaallah, Weirong Xing, Michael H. Walter, K.-H. William Lau, Xuezhong QinAnimal treatments and spinal cord sample collections were described in Figure 1 legend. (A–D) Real-time RT-PCR analysis of the relative levels of mRNA for MyD88 (A), IRF-4 (B), IBP (C), and Schalfen-4 (D). These downstream mediators of TLR8 signaling showed significant increase of mRNA expression in EAE and this increase was completely prevented by 1,25(OH)2D3 treatment. Data represent the means± SEM (n = 4) from one of two independent experiments. * P<0.05; ** P<0.01.
