Young CD8+ T Cell Model predictions of IP3 and Ca2+ in the various cellular compartments in response to TCR signaling in CD8+ T cells.
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Cytosolic Ca2+ dynamics in the absence (a) or presence of inhibitors (b,c) at the same concentration as for Jurkat cells. d-f) model predictions for other state variables in the no inhibitor simulation. The average trace across all optimized parameter sets is illustrated by the blue solid line and the shaded region represents the standard deviation of the dynamic behavior.