Working model of RanBP10-mediated subcellular transport during the nuclear import of HPV16.
figureposted on 2021-05-11, 17:36 authored by Kun-Yi Lai, Matteo Rizzato, Inci Aydin, Ruth Villalonga-Planells, Hannes C. A. Drexler, Mario Schelhaas
The L2 from incoming HPV16-PsV interacts with RanBP10, which interacts with cytosolic KPNA2 and thereby associates with MT-dependent motor proteins. The interaction forms a transport complex together with dynein motors that facilitates the subcellular trafficking of L2/vDNA complex. However, RanBP10 does not associate to mitotic chromosomes indicating a potential chromatin tethering factor still needs to be identified.