Working model of RanBP10-mediated subcellular transport during the nuclear import of HPV16.

The L2 from incoming HPV16-PsV interacts with RanBP10, which interacts with cytosolic KPNA2 and thereby associates with MT-dependent motor proteins. The interaction forms a transport complex together with dynein motors that facilitates the subcellular trafficking of L2/vDNA complex. However, RanBP10 does not associate to mitotic chromosomes indicating a potential chromatin tethering factor still needs to be identified.