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Women harbor several community state types (CST) that are differentially distributed between the study groups.

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posted on 2018-01-09, 18:33 authored by Simon Graspeuntner, Michael K. Bohlmann, Kathrin Gillmann, Runa Speer, Sven Kuenzel, Heike Mark, Friederike Hoellen, Reinhard Lettau, Georg Griesinger, Inke R. König, John F. Baines, Jan Rupp

Complete linkage clustering of samples based on the relative read count of bacteria and color key for study group assignment and CST (A). Heatmap showing relative read counts of the 25 most abundant bacterial taxa (B). Complete linkage clustering of the 25 most abundant bacterial taxa based on Spearman´s correlation coefficient (C). The samples cluster into CSTs and are named based on the respective dominant species as follows: Lcr: L. crispatus-dominated CST; Lin: L. iners-dominated CST; Lga: L. gasseri-dominated CST; Gva: G. vaginalis-dominated CST; div: diverse communities. Some single communities differ from these major community types and are comprised as Other. The distribution of the CSTs within study groups is shown in (D) (chi-square test: p<0.001). nININF: Non-infectious infertility; ININF: Infectious infertility; FSW: Female sex worker.