Wnt (in)dependency gene signatures of all Panc samples according to those identified by Seino et al.
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posted on 2024-04-10, 17:37 authored by Hayley J. Hawkins, Betelehem W. Yacob, Monica E. Brown, Brandon R. Goldstein, John J. Arcaroli, Stacey M. Bagby, Sarah J. Hartman, Morgan Macbeth, Andrew Goodspeed, Thomas Danhorn, Robert W. Lentz, Christopher H. Lieu, Alexis D. Leal, Wells A. Messersmith, Peter J. Dempsey, Todd M. Pitts[1]. Heatmap displaying Wnt (in)dependent gene signatures for all PDX PDAC tumor and organoid lines. Gene names as describe by Seino et al referenced in S2 Table. The dependency scores are generated using GSVA. The CPM of each gene was z-score transformed across each row. Pancreatic organoid lines compared to their respective PDX tumors. OPANC = organoid, PANC = PDX tumor.
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organoids demonstrating responseminimal media conditionstumor effect greaterpancreatic ductal adenocarcinomadiv >< pcombinatory treatment modalityreduced organoid growthkey wnt genesgrowth factor dependencydependent gene signaturescombinatory treatment effectptol )pancreatic cancer pdosproliferative effectpancreatic tumorsptol ).gene expressiondependent phenotypestreatment modalitieswnt signalingwnt inhibitorwnt dependencyvivo vitro thus fartherapeutic targettargeted therapysingle agentsphenotypes displayednude micecritical roleclinical utilizationadvanced stages
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