Why choose one when you can do BioChemistry!

Single-panel cartoon showing two laboratory researchers debating which approach—chemical or biological—to use for synthesising base-modified ATP. One holds a “Bio” book and a “Chem” book and asks which to try; the colleague cheerfully suggests doing both, capturing the spirit of chemo-enzymatic methods that merge organic chemistry with enzymology to generate tailored nucleotides for RNA polyadenylation. The whiteboard behind them sketches an RNA strand and reaction arrow, emphasising molecular biology context.

This cartoon abstract was prepared for the RSCPoster 2025 submission Chemo-enzymatic production of base-modified ATP analogues for polyadenylation of RNA by Nicolas Cornelissen.