posted on 2025-05-07, 20:18authored byVítor S. Fernandes, Ricardo Caballero, Marcos Siguero-Álvarez, Tania Papoutsi, Juan Ramón Gimeno-Blanes, Eva Delpón, José Luís de la Pompa
(A) Representative confocal image of myocardial sections exhibiting increased cardiomyocyte size in the Mib1flox;Tnnt2Cre mice. (B) Summary data showing that cardiomyocytes area (µm2)/ tibial (mm) ratio is increased in Mib1flox;Tnnt2Cre mice. (C) Summary data showing that cardiomyocyte capacitance is increased in Mib1flox;Tnnt2Cre mice. Statistical significance was determined by unpaired two-tailed Student’s t-test. To take into account repeated sample assessments, data were analysed with multilevel mixed-effects models. **P < 0.01; ****P < 0.0001 vs WT. In B, results are expressed as mean±SD of 400–600 cells from 3 animals per genotype. In C results are expressed as mean±SEM of 55–60 cells from 5 animals per genotype.