Volcano plot of differentially regulated genes in Slc13a4 heterozygous mice

We performed an RNA transcriptomic based sequencing screen on the whole forebrain from Slc13a4^+/- and Slc13a4^+/+mice at P20. Differential expression analysis revealed 90 differentially regulated genes in the forebrain of Slc13a4^+/- mice (a p-value of 0.1 was considered as significant). Of these, 55 were upregulated, and 35 were down downregulated in the forebrain of heterozygous mice. Moreover, when we stratified further with a ± 1.2 fold change, we observed 38 upregulated, and 18 down downregulated genes in the forebrain of heterozygous mice. This is shown in the volcano plot.