V(D)J recombination occurs in several steps

figure

posted on 2011-12-30, 13:59 authored by David B Roth

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Taken from "From lymphocytes to sharks: V(D)J recombinase moves to the germline"

Genome Biology 2000;1(2):reviews1014.1-reviews1014.4.

Published online 2 Aug 2000

PMCID:PMC138851.

First, the RAG proteins bind to the RSSs (triangles) and bring them together into a synaptic complex. Cleavage ensues, generating a pair of blunt signal ends and a pair of DNA hairpin coding ends. Joining of these ends generates signal and coding joints, respectively. The boxes represent V, D or J coding elements.

V(D)J recombination occurs in several steps

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