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VZV infected NK cells produce less IFN-γ and TNF upon PMA/I stimulation.

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posted on 13.06.2019, 17:53 by Tessa Mollie Campbell, Brian Patrick McSharry, Megan Steain, Tiffany Ann Russell, David Carl Tscharke, Jarrod John Kennedy, Barry Slobedman, Allison Abendroth

PBMCs were mock cultured, exposed to VZV, or VZV infected for 2 days (A) or 1 day (B) and stimulated with PMA/I for flow cytometry analysis of IFN-γ (top panels) or TNF (bottom panels) expression by NK cells (viable CD3CD56+ cells). Symbols represent individual donors, and grey columns indicate mean. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns = not significant (Repeated measures one-way ANOVA with Tukey correction (A) or Friedman test with Dunn’s correction (B)). Data are from nine donors (A) or seven donors (B).